Weight Loss Drugs Cause Rebound Effect

The meta-analysis examined data from 11 randomized trials involving over 2,400 participants across multiple countries. Researchers tracked what happened when people stopped taking anti-obesity medications (AOMs), including the widely prescribed GLP-1 drugs, such as semaglutide (Ozempic, Wegovy) and tirzepatide.

The results paint a concerning picture of dependency and metabolic disruption that pharmaceutical companies haven’t been eager to discuss.

Researchers discovered a predictable pattern of weight regain that begins almost immediately after stopping these medications.  At four weeks post-discontinuation, patients still maintained some weight loss.  However, by eight weeks, significant weight regain had begun, continuing for an average of 20 weeks before stabilizing.