In a recent study published in npj Women’s Health, researchers investigated whether the timing of a woman’s COVID-19 vaccination within her menstrual cycle is associated with self-reported side effects and exploratory measures of subsequent infection timing.
The study analyzed data from Clue (a popular period-tracking application), comprising an analytical dataset of 1,474 individuals. The analyses focused on matching logged menstrual data with participants’ self-reported vaccine experiences.
Study findings showed that individuals vaccinated during the estrogen-dominant follicular phase had 35% higher odds of self-reporting any side effects than those vaccinated during the progesterone-dominant luteal phase.
Furthermore, the data showed a longer median self-reported time to breakthrough infection among those vaccinated during the follicular phase, although this finding was exploratory and underpowered.
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