Investigators from Mass General Brigham have conducted a multi-ancestry, whole genome sequencing association study of Alzheimer's disease and found evidence for 16 new susceptibility genes, expanding the study of Alzheimer's disease in underrepresented groups. The work is published in the Alzheimer's & Dementia journal.
For the study, co-led by Julian Daniel Sunday Willett, MD, Ph.D., and Mohammad Waqas, of the Genetics and Aging Research Unit and McCance Center for Brain Health at Massachusetts General Hospital, researchers used whole-genome sequencing and a cohort of 49,149 individuals. The study included 12,074 participants who were clinically diagnosed with Alzheimer's disease and 37,075 diagnosed due to their family history.
