The intestinal lining acts as a barrier between the gut contents and the rest of the body. Typically, this barrier selectively allows nutrients to pass into the bloodstream while preventing potentially harmful substances, such as bacteria and toxins, from escaping the intestine.
When this barrier becomes compromised, harmful molecules can enter the bloodstream, potentially triggering immune responses and inflammation.
This process, often described informally as leaky gut syndrome, is associated with various digestive disorders, such as Celiac disease, inflammatory bowel disease (IBD), and irritable bowel syndrome (IBS).
Although the importance of maintaining intestinal barrier integrity has long been recognized, the exact mechanisms involved have remained incompletely understood.
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