A new analysis suggests that people who stop taking Ozempic-like medications keep off about 25 percent of the weight they lost, up to a year later. But here's the catch: it's not known how much of this weight loss is muscle rather than fat.
This medical mystery highlights an underexplored consequence of semaglutide, tirzepatide, and other drugs prescribed to manage type 2 diabetes or body weight. Some initial studies indicate that 40 to 60 percent of the weight lost during treatment may constitute lean muscle mass.
While it's well documented that patients regain weight after discontinuing these medications, it's not clear what the pounds are comprised of.
"If the regained weight is disproportionately fat, individuals may ultimately be worse off than before in their fat-to-lean mass ratio, which may have adverse consequences for their health," explains medical researcher Brajan Budini, co-first author of the study by a team at the University of Cambridge in the UK.
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