New study has discovered a groundbreaking technology that is showing remarkable success in significantly reducing bad cholesterol and triglycerides in a single treatment. This scientific advancement offers a potential future where managing heart health may involve one-time interventions rather than daily routines. While still in early stages, this breakthrough underscores the enduring importance of everyday healthy habits for cardiovascular wellness.
Heart disease is the world’s leading cause of death across the world but a new scientific chapter may be unfolding. What if managing cholesterol did not always mean daily pills, relentless diet tracking or stressing about missed doses? According to a recent trial published in The New England Journal of Medicine, gene-editing technology known as CRISPR has been used in humans to sharply lower levels of “bad” cholesterol and triglycerides in a single treatment. Take a look.
What this means for you is that the path to a healthier heart is not only new drugs or stricter diets, it might also be about smarter treatments combined with everyday habits. The results of the study were presented Saturday, November 08, 2025, at the American Heart Association's annual meeting. Here is what the science says and how you can stay in control of your cardiovascular wellness.
Science snapshot: One-and-done vs life-long routine
The trial in question involved a small group of adults whose cholesterol remained high despite existing therapies. Researchers targeted a gene in the liver called ANGPTL3 using CRISPR, turning it off in order to mimic rare protective mutations found in some people. In this study, LDL cholesterol and triglycerides dropped by about 50% within weeks.
The main point to emphasize here is that a single gene modification has the potential to significantly reduce, if not completely eliminate, the necessity for patients to depend on daily medication regimens.
